A However, we have recently discovered that a significant number of these individuals may have a major genetic component that contributes to the disease. Dry macular degeneration, in which the cells of the macula slowly begin to break down, is diagnosed in 90 percent of the cases. Yellow deposits called "drusen" form under the retina between the retinal pigmented epithelium (RPE) and Bruch’s membrane, which supports the retina. Drusen deposits are "debris" associated with compromised cell metabolism in the RPE and are often the first sign of macular degeneration. Eventually, there is a deterioration of the macular regions associated with the drusen deposits resulting in a spotty loss of "straight ahead" vision. Wet macular degeneration occurs when abnormal blood vessels grow behind the macula, then bleed. There is a breakdown in Bruch’s membrane, which usually occurs near drusen deposits and this is where the new blood vessel growth occurs (neovascularization). These vessels are very fragile and leak fluid and blood (hence ‘wet’), resulting in scarring of the macula and the potential for rapid, severe damage. "Straight ahead" vision can become distorted or lost entirely in a short period of time, sometimes within days. Wet macular degeneration accounts for approximately 10% of the cases, however it results in 90% of the legal blindness. What does macular degeneration do to your vision? What are the Symptoms of Macular Degeneration? What can you or your loved one do if diagnosed with macular degeneration?
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Adult macular degeneration is traditionally described as that form of the disease that affects individuals over the age of 55 years.